Abstract: The case of a 59-year-old woman lacking bone in the lower left side of her mandible,
and treated with two different biomaterials for bone regeneration, is reported here. Specifically,
two different anatomical sites damaged by two different pathologies were studied: a radicular
fracture and peri-implantitis. The sites were treated via xenograft bone substitute and calcium
phosphosilicate, respectively. Follow-up evaluations showed that the two different methodologies
employing different materials in the same organism undergoing the same metabolic processes
achieved the same good results. This represents a significant change in current surgical strategies for
the dental region: instead of focusing on a single gold-standard technique, it is possible to follow a
hybrid approach by adapting the biomaterial and the protocol used to the specificities of the defect.