Abstract

Scaffolds for bone regeneration should ensure both mechanical stability and strength. Moreover, their intimate structure should have an adequate interconnected porous network for cell migration and proliferation, while also providing specific signals for bone regeneration. SmartBone® composite solution, based on a novel concept of biomaterial assembly, bearing cues from both mineral components and polymeric ones [1-3], was chosen to develop new patient-specific three-dimensional bone grafts. Indeed, thanks to mechanical performances and to full control over production, custom-made bone grafts can be produced according to the specific need of each single patient, via digital surgical planning, starting from CT scans.

http://www.ecmjournal.org